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What is the difference between carbon monoxide and carbon dioxide? - When referring to carbon monoxide (CO) and carbon dioxide (CO2), people often confuse or interchange the two. For the most part, people are aware that they are two different gases, but which one is the good one and which is the bad one, or is it even correct to classify them that way? Before getting into how and where carbon monoxide and carbon dioxide affect people and the environment and how to test for them, let’s get a basic understanding of where they come from.